Substrate: Thrombin receptor (G protein coupled receptor)
Seq-ID: P25116 [Homo sapiens]
Download:fasta csv
Interaction Network(s): STRING   NetworKIN  
External Source(s): Phosida
MINT Interaction(s):-
GO-Terms:
[show]
Molecular FunctionCellular ComponentBiological Process
thrombin receptor activity,
receptor binding		 platelet dense tubular network,
caveola,
integral to plasma membrane,
Golgi apparatus		 positive regulation of MAPKKK cascade,
platelet dense granule organization,
STAT protein nuclear translocation,
positive regulation of I-kappaB kinase/NF-kappaB cascade,
positive regulation of cell migration,
negative regulation of cell proliferation,
positive regulation of release of sequestered calcium ion into cytosol,
positive regulation of transcription, DNA-dependent,
activation of caspase activity,
anatomical structure morphogenesis,
positive regulation of blood coagulation,
connective tissue replacement involved in inflammatory response wound healing,
platelet activation,
positive regulation of collagen biosynthetic process,
positive regulation of JAK-STAT cascade,
tyrosine phosphorylation of STAT protein
Conservation:
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Res. Pos. Sequence Kinase PMID Src Cons. ELM Binding Domain SMART/Pfam IUPRED score PDB P3D Acc.
S 375 CIDPLIYYYASSECQRYVYSI - 8955127
LTP
1.00
 - -
0.00
 - medium
S 376 IDPLIYYYASSECQRYVYSIL - 8955127
LTP
0.29
 - -
0.00
 - medium
Y 383 YASSECQRYVYSILCCKESSD - 15023990
LTP
0.07
 - -
0.01
 - medium
S 384 ASSECQRYVYSILCCKESSDP - 8955127
LTP
0.19
 - -
0.01
 - medium
S 391 YVYSILCCKESSDPSSYNSSG - 8955127
LTP
0.21
 - -
0.02
 - medium
S 392 VYSILCCKESSDPSSYNSSGQ - 8955127
LTP
0.07
 - -
0.02
 - medium
S 395 ILCCKESSDPSSYNSSGQLMA - 8955127
LTP
0.77
 - -
0.06
 - medium
S 396 LCCKESSDPSSYNSSGQLMAS - 8955127
LTP
0.26
 - -
0.10
 - medium
Y 397 CCKESSDPSSYNSSGQLMASK - 8955127
LTP
0.49
 - -
0.12
 - medium
S 399 KESSDPSSYNSSGQLMASKMD - 8955127
LTP
0.26
 - -
0.15
 - medium
S 400 ESSDPSSYNSSGQLMASKMDT - 8955127
LTP
0.97
 - -
0.17
 - medium
S 406 SYNSSGQLMASKMDTCSSNLN - 8955127
LTP
0.14
 - -
0.09
 - medium
T 410 SGQLMASKMDTCSSNLNNSIY - 8955127
LTP
0.21
 - -
0.06
 - medium
S 412 QLMASKMDTCSSNLNNSIYKK - 8955127
LTP
0.24
 - -
0.04
 - medium
S 413 LMASKMDTCSSNLNNSIYKKL - 8955127
LTP
1.00
 - -
0.04
 - medium
S 418 MDTCSSNLNNSIYKKLLT    - 8955127
LTP
0.30
 - -
0.04
 - medium
T 425 LNNSIYKKLLT           - 8955127
LTP
0.00
 - -
0.03
 - medium

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